|本期目录/Table of Contents|

[1]林希,吴江渝*.超支化聚酰胺胺的合成及季胺化修饰[J].武汉工程大学学报,2010,(11):73-76.[doi:10.3969/j.issn.16742869.2010.11.019]
　LIN Xi,WU Jiang yu.Synthesis and modification of hyperbranced PAMAM[J].Journal of Wuhan Institute of Technology,2010,(11):73-76.[doi:10.3969/j.issn.16742869.2010.11.019]
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超支化聚酰胺胺的合成及季胺化修饰(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2010年11期
页码:
73-76
栏目:
资源与土木工程
出版日期:
2010-11-30

文章信息/Info

Title:
Synthesis and modification of hyperbranced PAMAM
文章编号:
16742869(2010)11007304
作者:
林希; 吴江渝*
武汉工程大学材料科学与工程学院,湖北 武汉 430074
Author(s):
LIN Xi;  WU Jiangyu
School of Material Science and Engineering,Wuhan Institute of Technology,Wuhan 430074,China
关键词:
超支化聚合物; 聚酰胺胺; 修饰; 季铵盐
Keywords:
hyperbranched ploymer;  PAMAM;  modification;  quaternary ammonium salt
分类号:
O633.4
DOI:
10.3969/j.issn.16742869.2010.11.019
文献标志码:
A
摘要:
树形聚酰胺胺分子因其良好的生物相容性而在生物方面有广泛应用,但由于合成步骤繁琐,后处理复杂,使得其成本高昂.超支化聚酰胺胺的结构和性能与树形聚酰胺胺有相似之处,由于其合成方法简单,可降低成本,作为树形分子的代替品.本文采用乙二胺和丙烯酸甲酯反应生成ABn预聚物,通过逐步升温使其聚合成有高分子量和高度支化结构的超支化聚酰胺胺,并对其伯胺端基进行修饰,期望合成具有良好抑菌效果的季胺盐.
Abstract:
Although dendritic PAMAMs molecules have wide range of application in biological field due to their good biocompatibility, the complex procedure of synthesis and multistep of post treatment lead to high cost. Dendritic PAMAM can be taken place by hyperbranched PAMAM, with simple prepared method and similarities between them. In the article ABntype prepolymer can be formed by the reaction of diaminoethane and methyl acrylate, and further polymerization of the prepolymer can generate hyperbranched PAMAM with high molecule weight and hyperbranched architecture under stepwise temperature rise. Finally, modification of primary amine terminal group of the hyperbranced PAMAM can create the quaternary ammonium salt with antibacterial efficacy.

参考文献/References:

［1］Turner S R, Voit B I. The Hyperbranched PAMAM［J］.Polymer News,1997,22:197201.
［2］ Buhleier E,Wehner W,Vgtle F.“Cascade” and“Nonskidchainlike” syntheses of molecular cavity topologies［J］.Synthesis,1978,78: 155158.
［3］Kim Y H.Webster.Hyperbranched polyphenylenes［J］.Polym,Prepr,1988,29(2):310311.
［4］高超.超支化聚合物的分子设计合成表征及功能化研究［D］.上海:上海交通大学,2001.
［5］吴江渝.新型聚酰胺胺树形分子的合成、表征和生物活性研究［D］.武汉:武汉大学,2004.
［6］杨武利.超支化聚酰胺胺及其共聚物的合成与性质［J］.化学世界,2005,62:5759.
［7］Jun Chen,Chao Wu, David Oupicky.Bioreducible hyperbranched poly(amidoamine)s for gene delivery［J］.Biomacromolecules,2009,10:29212927.
［8］Youyi Sun, Yaqing Liu, Zhao Guizhe,et al.Effects of hyperbranched poly(amidoamine)s generation number on synthesis of Ag nanoparticles［J］.Polym Res,2008,15:269273.
［9］刘翠华.超支化聚合物的合成及其超分子封装和超分子自组装研究［D］.上海:上海交通大学,2007.
［10］曹亮.超支化聚酰胺胺的合成及功能化应用［D］.上海:上海交通大学,2005.
［11］Liu Cuihua,Gao Chao,Yan Deyue.Aliphatic hyperbranched poly(amido amine)s (PAMAMs)：Preparation and Modification［J］.Chem Res Chinese U.2005,21(3):345354.
［12］简科.生物医用高分子材料研究进展［C］//中国化学会第12届反应性高分子(离子交换与吸附)学术研讨会会议论文集.北京：中国化学会,2004:124125.
［13］张幼珠,吴徽宇,田保中.药物丝素膜的性能及在烧伤感染创面上的应用［J］.纺织学报,2001,22(3): 4042.

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备注/Memo

备注/Memo:
龚晓宁收稿日期：20100601作者简介：林希(1986)，女，湖北武汉人，硕士研究生.研究方向：超支化聚合物、聚酰胺胺、生物高分子.指导老师：吴江渝，男，博士.研究方向：生物医用高分子材料的研究与开发.
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