[1]鄢　龙,傅　晶,吴　莉,等.CDK4/6抑制剂abemaciclib合成工艺的优化[J].武汉工程大学学报,2018,40(02):149-155.[doi:10. 3969/j. issn. 1674?2869. 2018. 02. 006]
　YAN Long,FU Jing,WU Li,et al.Synthetic Process Optimization of CDK4/6 Inhibitor Abemaciclib[J].Journal of Wuhan Institute of Technology,2018,40(02):149-155.[doi:10. 3969/j. issn. 1674?2869. 2018. 02. 006]

点击复制

CDK4/6抑制剂abemaciclib合成工艺的优化(/HTML)

分享到：

参考文献/References:

［1］　DIGIULIO S． FDA’s breakthrough therapy designation to abemaciclib for breast cancer ［J］.Oncology Times，2015，37（21）：21.［2］　PATNAIK A，ROSEN L S，TOLANEY S M，et al．Abstract CT232： clinical activity of LY2835219，a novel cell cycle inhibitor selective for CDK4 and CDK6，in patients with metastatic breast cancer ［J］. Cancer Research， 2014，74（19）：CT232.［3］　KIM E S. Abemaciclib： First global approval［J］. Drugs，2017，77（18）：2063-2070.［4］　FREDERICK M O， KJELL D P．A synthesis of abemaciclib utilizing a Leuckart-Wallach reaction ［J］.Tetrahedron Letters，2015，56（7）：949-951.［5］　张浩，张剑，陈奉泉. Abemaciclib合成路线图解［J］. 药物化学， 2016， 4（4）：38-41.［6］　YUE X L，LI H，LIU S S，et al． N-fluorinated phenyl- N ′-pyrimidyl urea derivatives： synthesis，biological evaluation and 3D-QSAR study ［J］. Chinese Chemical Letters，2014，25（7）：1069-1072.［7］　KATRITZKY A R，CAI C，SINGH S K． Efficient microwave access to polysubstitutedamidines from imidoylbenzotriazoles ［J］. Cheminform，2006，71（9）：3375-3380.［8］　LIUBCHAK K， NAZARENKO K，TOLMACHEV A．Cheminform abstract： synthesis of annulated benzimidazoles via amidine cyclization ［J］. Tetrahedron，2012， 68（14）：2993-3000.［9］　INFANTE-CASYILLO R，HERNANDEA-RIVERA S P. Experimental and theoretical studies of the molecular structure of five new 2-methylbenzimidazole derivatives ［M］. New York： Nova Science Publishers，2011：11.［10］　蔡雄，钱长庚，刘斌，等.吡啶嘧啶胺类化合物或吡啶吡啶胺类化合物及其应用：中国，105153119A ［P］.2015-09-11.［11］　SANCHEZ- MARTINEZ C. Preparation of benzimidazolylpyrimidinylaminopyridines as CDK4/6 protein kinase inhibitors：US，20100160340A1 ［P］. 2010-07-24.［12］　DZHEVAKOV P B，TOPCHIY M A，ZHARKOVA D A，et al．Miyauraborylation and one-pot two-step homocoupling of aryl chlorides and bromides under solvent-freeconditions ［J］. Advanced Synthesis & Catalysis，2016，358（6）：977-983.［13］　PLETZ J，BERG B， BREINBAUER R．Cheminform abstract： a general and direct reductive amination of aldehydes and ketones with electron-deficient anilines ［J］. Synthesis，2016，48（9）：1301-1317.［14］　ABDELMAGID A F，CARSON K G， HARRIS B D， et al． Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride．Studies on direct and indirect reductive amination procedures ［J］. Journal of Organic Chemistry，1996， 61（11）：38-49.［15］　MATTSON R J，PHAM K M，LEUCK D J，et al．Cheminform abstract： an improved method for reductive alkylation of amines using Titanium（IV） isopropoxide and sodium syanoborohydride ［J］.Cheminform，1990，21（41）：2552-2554.［16］　BOSCHELLI D H，WU B，BARRISO S A C，et al． Inhibition of src kinase activity by 7-［（2，4- dichloro-5-methoxyphenyl）amino］- 2-heteroaryl-thieno［3，2-b］pyridine-6-carbonitriles［J］. Bioorganic & Medicinal Chemistry Letters，2005，15（21）：4681-4687.［17］　COATES D A，GELBERT L M， KNOBELOCH J M， et al． Protein kinase inhibitors： US，7855211 ［P］. 2010-12-21.［18］　ANDREW C D， ALFONSO D，ANA D，et al． Protein kinase inhibitors：WO， 2010075074A1［P］. 2010-07- 24.［19］　CHAN E M． Combination therapy for cancer：WO， 2015130540A1［P］.2015-09-03.［20］　LIAO B S， LIU S T． Homogenous bimetallic catalysis on amination of ArX and ArX2 in aqueous medium-synergistic effect of dicopper complexes ［J］. Catalysis Communications，2013，32（5）：28-31.［21］　ELMKADDEM M K， FISCHMEISTER C， THOMAS C M， et al．Cheminform abstract： efficient synthesis of aminopyridine derivatives by copper catalyzed amination reactions ［J］. Chemical Communications，2010，46（6）：925.［22］　WANG Y， LUO J， LIU Z ．Cheminform abstract：synthesis of a novel 8-hydroxyquinoline functionalized poly（ethylene glycol） bridged dicationic ionic liquid and its application in palladium-catalyzed Heck reaction under solvent-free conditions［J］. Journal of Organometallic Chemistry，2014，44（46）：1-5.［23］　WOLINSKA E． Sequential amination of heteroaromatic halides with aminopyridine 1-oxides and their N-protected derivatives based on novel aza-smiles rearrangement ［J］. Heterocyclic Comm- unications，2012，18（5/6）：227-232.［24］　BONNATERRE F， BOIS-CHOUSSY M， ZHU J． Rapid access to oxindoles by the combined use of an ugifour-component reaction and a microwave-assisted intramolecular Buchwald-Hartwig amidation reaction ［J］. Organic Letters，2006，8（19）：4351-4354.

相似文献/References: