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[1]金士威,程巧红,戴和平.不同基因缺失型酵母对全氟辛酸的灵敏性[J].武汉工程大学学报,2012,(9):5-8.[doi:103969/jissn16742869201209002]
　JIN Shi wei,CHENG Qiao hong,DAI He ping.Sensitivity of different gene deletion yeast to perfluorooctanoic acid[J].Journal of Wuhan Institute of Technology,2012,(9):5-8.[doi:103969/jissn16742869201209002]
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不同基因缺失型酵母对全氟辛酸的灵敏性(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2012年9期
页码:
5-8
栏目:
化学与化学工程
出版日期:
2012-10-10

文章信息/Info

Title:

Sensitivity of different gene deletion yeast to
perfluorooctanoic acid
文章编号:
16742869(2012)09000504
作者:
金士威1; 程巧红1;  戴和平2
1．武汉工程大学化工与制药学院，绿色化工过程教育部重点实验室，湖北 武汉 430074；
2. 中国科学院水生生物研究所，淡水生态与生物技术国家重点实验室，湖北 武汉 430072
Author(s):
JIN Shiwei1;  CHENG Qiaohong1;  DAI Heping2
1. School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Key Laboratory for Green Chemical
Process of Ministry of Education, Wuhan 430074, China；
2. Institute of hydrobiology, Chinese academy of sciences, State Key Laboratory of Freshwater Ecology and Biotechnology,
Wuhan 430072, China
关键词:
基因缺失型酵母突变体; 基因缺失型酵母突变体; 毒性机理
Keywords:
genes deletion yeast mutant;  genes deletion yeast mutant; mechanism of toxicity
分类号:
X835
DOI:
103969/jissn16742869201209002
文献标志码:
A
摘要:
针对全氟化合物这类新型的有机污染物，在环境中具有持久性，生物累积性和毒性的问题，以全氟辛酸为模型化合物，以真核生物酵母以及4基因缺失型酵母突变体和5基因缺失型酵母突变体为模式生物，开发便捷、灵敏的毒理学评价方法，探究全氟辛酸对不同基因缺失型酵母的毒性效应，以期建立以酵母为平台的环境污染物快速筛选系统.研究结果表明，5基因缺失型酵母突变体对全氟辛酸较为敏感，可以作为建立环境污染物快速筛选系统的细胞模型.
Abstract:
Perfluorinated compounds (PFCs) are a class of emerging organic contaminants with persistent stability, strong bioaccumulation and high toxicity. To develop a convenient, sensitive toxicological evaluation method, perfluorooctanoic acid（PFOA）was used as a model compound and eukaryotic yeast and its 4 genes deletion yeast mutant and 5 genes deletion yeast mutant were used as model organisms. The toxic effects of PFOA on different gene deletion yeast were studied. The results show that 5 genes deletion yeast mutant is more sensitive to PFOA, which can be used as a cell model to establish rapid screening system of environmental pollutants.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：20120705基金项目：国家自然科学基金重点项目(21037004)作者简介：金士威(1972)，男，浙江东阳人，教授，博士,硕士研究生导师.研究方向：持久性有机污染监测与生态毒理学.
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