|本期目录/Table of Contents|

[1]申永存,李倩,夏定,等.双（3，5\|二甲基苯基）膦的合成[J].武汉工程大学学报,2012,(05):13-15.[doi:103969/jissn16742869201205004]
　SHEN Yong\|cun,LI Qian,XIA Ding,et al.Preparation of bis (3,5\|dimethylphenyl)phosphine[J].Journal of Wuhan Institute of Technology,2012,(05):13-15.[doi:103969/jissn16742869201205004]
点击复制

双（3，5\|二甲基苯基）膦的合成
(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2012年05期
页码:
13-15
栏目:
化学与化学工程
出版日期:
2012-05-31

文章信息/Info

Title:
Preparation of bis (3,5\|dimethylphenyl)phosphine
文章编号:
16742869(2012)05001303
作者:
申永存; 李倩; 夏定; 陈世坤
武汉理工大学化工学院，湖北 武汉 430070
Author(s):
SHEN Yong\|cun; LI Qian;  XIA Ding;  CHEN Shi\|kun
Institute of chemical engineering ,Wuhan University of Technology ,Wuhan 430070,China
关键词:
膦配体; 二异丁基氢化铝; 还原
Keywords:
phosphorus ligands;  DIBAL;  deoxidized
分类号:
TQ457.2
DOI:
103969/jissn16742869201205004
文献标志码:
A
摘要:
为了推动在国内尚无商业化产品的双（3,5\|二甲基苯基）膦在不对称催化合成精异丙甲草胺中应用，对双（3,5\|二甲基苯基）膦的合成工艺进行了研究.以双（3,5\|二甲基苯基）氧膦为原料，通过二异丁基氢化铝还原得到双（3,5\|二甲基苯基）膦，最佳条件为：双(3,5\|二甲基苯基)氧膦与二异丁基氢化铝摩尔比为1∶3，溶剂为四氢呋喃，反应温度65 ℃，反应时间1 h，产率为89%.实验结果表明：该方法操作简单，副反应少且容易控制.
Abstract:
Bis(3,5\|dimethyl phenyl)phosphine is an effective ligand for asymmetric synthesis of S\|metolachlor and there is no commercial product in domestic at present.In order to promote the development of asymmetric synthesis process of S\|metolachlor, the synthetic process was studied in this paper.With bis(3,5\|dimethyl phenyl)phosphine oxide as raw material, bis(3,5\|dimethyl phenyl)phosphine was synthesized by deoxidization through diisobutyl aluminium hydride,and the optimal conditions were the ration of bis(3,5\|dimethyl phenyl) phosphine oxide to diisobutyl aluminum hydridemole of 1∶3，reaction temperature of 65 ℃, reaction time of 1 h，and the production rate of 89% .The results show that this method is simple, and easy to control with less side reactions.

参考文献/References:

［1］刘志俊. 异丙甲草胺（精异丙甲草胺）：开拓市场恰逢其时［J］. 山东农药信息, 2005(6)：28-30.
［2］O’Connell P J, Harms C T, Allen J R F. Metolachlor, S-metolachlor and their role within sustainable weed management ［J］. Crop Protect, 1998, 17(3): 207-212.
［3］Chen W, Mbafor W, Roberts S M, et al. A very simple, highly stereoselective and modular synthesis of ferrocene-based P-chiral phosphine ligands［J］. J Am Chem Soc，2006, 128(12): 3922-3923.
［4］Kuwano R, Sato K, Kurokawa T, et al. Catalytic asymmetric hydrogenation of heteroaromatic compounds, indoles［J］. J Am Chem Soc，2000, 122(31): 7614-7615.
［5］Boaz N, Debenham S D, Mackenzie E B, et al. Phosphinoferrocenylamino phosphines as novel and practical ligands for asymmetric catalysis［J］. Org Lett，2002, 4(14): 2421-2424.
［6］Wang D Y, Hu X P, Hou C J, et al. Enantioselective Rh\|catalyzed hydrogenation of 3\|Aryl\|2\|phosphonomethylpropenoates by a New class of chiral ferrocenyl diphosphine ligands ［J］. Org Lett，2009, 11(15): 3226-3229.
［7］Morris M P. A method for generating secondary phosphines：WO，068479 A1［P］.2005- 07-28.

相似文献/References:

备注/Memo

备注/Memo:
收稿日期：20120426作者简介：申永存(1966-)，男，湖北武汉人，教授，博士，硕士研究生导师.研究方向：新药的合成与筛选、不对称合成、抗病毒药物的合成及工艺．
更新日期/Last Update: