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[1]杨卉,丁一刚*,杨昌炎,等.咪唑合成工艺优化[J].武汉工程大学学报,2011,(11):19-22.
　YANG Hui,DING Yi gang,YANG Chang yan,et al.Optimization for imidazole synthesis[J].Journal of Wuhan Institute of Technology,2011,(11):19-22.
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年11期
页码:
19-22
栏目:
化学与化学工程
出版日期:
2011-11-30

文章信息/Info

Title:
Optimization for imidazole synthesis
文章编号:
16742869(2011)11001904
作者:
杨卉; 丁一刚*; 杨昌炎; 夏云; 杨光宏; 张丽丽; 魏云
武汉工程大学化工与制药学院，湖北省新型反应器与绿色化学工艺重点实验室，
绿色化学工程省部共建教育部重点实验室,湖北 武汉 430074
Author(s):
YANG Hui; DING Yigang; YANG Changyan; XIA Yun; YANG Guanghong; ZHANG Lili; WEI Yun
School of Chemical Engineering&Pharmacy,Hubei Key Lab of Novel Reactor& Greeen Chemical Technology,
Wuhan Institute of Technology,Wuhan 430074，China
关键词:
咪唑; 合成; 碳酸氢铵
Keywords:
imidazole; synthesis technology; ammonium bicarbonate
分类号:
TQ252.3
DOI:
-
文献标志码:
AAdoi:10.3969/j.issn.16742869.2011.11.005
摘要:
通过对现有工业上乙二醛法合成咪唑的方法改进，选择价廉易得的碳酸氢铵作为环合剂，改变温度、反应时间、原料配比，并结合单因素实验和正交实验法对实验数据进行统计与分析，得到碳酸氢铵合成咪唑的最佳工艺条件.
Abstract:
 The existing industrial synthesis method of imidazole was improved，whose main material was glyoxal.The cheap ammonium bicarbonate was selected as a ring mixture.Through changing temperature,reaction time and the ratio of raw materials,and combined with the single factor experiment and the orthogonal experiment method of the experimental data statistics and analysis，the optimum technological conditions for ammonium bicarbonate of imidazole synthesis were obtained.

参考文献/References:

［1］伍晓春.咪唑类化合物的合成与应用研究［J］.精细与专用化学品，2010(7）：5155.
［2］陆忠民,刘炘正.咪唑合成工艺综述［J］.化工时刊,1999,13(2):2627.
［3］蒋宗林,鄢家明,谢如刚.咪唑环合成方法的新进展［J］.合成化学,1998,6(1):1118.
［4］Schulze H.Imidazole synthesis:US，3715365［P］.19730206.
［5］Wang Z R.Comprehensive Organic Name Reactions and Reagents［M］.New Jersey：John Wiley & Sons,Inc,2009.
［6］孟晖.咪唑及其同系物开发与应用［J］.化工文摘,2004(4):2930.

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