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[1]肖芳,周霁,严少康,等.HPLC法测定癸氧喹酯固体分散体有关物质及其含量[J].武汉工程大学学报,2011,(08):56-59.
　XIAO Fang,ZHOU Ji,YAN Shaokang,et al.Determination of decoquinate dispersions of solid by HPLC method[J].Journal of Wuhan Institute of Technology,2011,(08):56-59.
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年08期
页码:
56-59
栏目:
化学与化学工程
出版日期:
2011-09-30

文章信息/Info

Title:
Determination of decoquinate dispersions of solid by HPLC method
文章编号:
16742869（2011）08005604
作者:
肖芳; 周霁; 严少康; 黎璐平; 刘永琼*
武汉工程大学化工与制药学院，绿色化工过程省部共建教育部重点实验室，
湖北省新型反应器与绿色化学工艺重点实验室，湖北 武汉 430074
Author(s):
XIAO Fang; ZHOU Ji; YAN Shaokang; LI Luping; LIU Yongqiong*
School of Chemical Engineering & Pharmacy，Wuhan Institute of Technology，
Key Laboratory for Green Chemical Process of Ministry of Education，
Hubei Key Laboratory of Novel Chemical Reactor & Green Chemical Technology，Wuhan 430074，China
关键词:
高效液相色谱法; 癸氧喹酯固体分散体; 有关物质; 定量分析
Keywords:
HPLC;  decoquinate dispersions of solid; related matter; quantitative analysis
分类号:
R927.2
DOI:
-
文献标志码:
AAdoi:10.3969/j.issn.16742869.2011.08.014
摘要:
采用高效液相色谱（HPLC）法测定癸氧喹酯固体分散体的有关物质及含量，用C18色谱柱（Dionex 5 μm，4.6 mm×250 mm），以无水甲醇为流动相，流动相速度为1.0 mL/min，柱温为30 ℃，检测波长为265 nm.结果发现癸氧喹酯固体分散体在1.0~50 mg/mL浓度范围内呈良好线性关系（R2=0999 8）；平均回收率为1013%；RSD为084%；检测线为0.05 mg/mL.结果表明:本法可快速、准确地测定癸氧喹酯固体分散体的含量和有关物质，适用于产品的质量控制
Abstract:
Established a method for determination of decoquinate disperisions of solid with high performance liquid chromatography (HPLC). The HPLC method was carried on C18 (4.6 mm×250 mm,5 μm) column using anhydrous methanol as mobile phase.The flow rate was 1 mL/min.The column temperature was 30 ℃ and detection wavelength was 265 nm.The result showed the calibration curve for decoquinate dispersions of solid was linear in the range of 1.0-50 mg/mL（R2=0.999 8）. The average recovery of decoquinate dispersions of solid was 1013%, with RSD 0.84%,the detected limit was 0.05 mg/mL. The method which was rapid,simple, accurate and suitable for the quality control of the drug was found in the research.

参考文献/References:

［1］都业良.癸氧喹酯对AA肉鸡感染Eimeria tenella 疗效的研究［J］.中国农学通报，2009，25（4）：69.
［2］Williams R B. Tracing the emergence of drugresistance in coccidia (Eimeria spp.) of commercial broiler flocks medicated with decoquinate for the first time in the United Kingdom［J］. Vet Parasitol, 2006, 135:114.
［3］中国兽药典委员会．中华人民共和国兽药典［M］．北京：中国农业出版社，2005：附录97，225.
［4］周玉武，栾明娜，徐福亮，等．高效液相色谱法测定癸氧喹酯溶液的含量［J］．中国兽药杂志，2009,43(2):3234.
［5］李嘉宇，戴正琳．HPLC法测定非诺贝特软胶囊的有关物质及含量［J］．武汉工程大学学报，2009（12）：2123.
［6］祁雯雯，李俊杰，刘永琼，等．妥曲珠利固体分散物的制备［J］．中国兽药杂志，2009，43(4)：3437.
［7］刘文英.药物分析［M］.5版.北京:人民卫生出版社,2006：8083.

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