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[1]李萤,刘永琼*,祝宏,等.维生素C泡腾片主组分的吸湿性[J].武汉工程大学学报,2009,(05):14-17.
 LI Ying,LIU Yong qiong,ZHU Hong,et al.The study of major content in Vitamin Ceffervescence tablet on moisture absorption[J].Journal of Wuhan Institute of Technology,2009,(05):14-17.
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维生素C泡腾片主组分的吸湿性(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2009年05期
页码:
14-17
栏目:
化学与化学工程
出版日期:
2009-05-28

文章信息/Info

Title:
The study of major content in Vitamin C
effervescence tablet on moisture absorption
文章编号:
16742869(2009)05001404
作者:
李萤刘永琼*祝宏李俊杰李胜松
武汉工程大学化工与制药学院,绿色化工过程省部共建教育部重点实验室,湖北 武汉 430074
Author(s):
LI YingLIU YongqiongZHU HongLI JunjieLI Shengsong
School of Chemical Engineering & Pharmacy,Wuhan Institute of Technology,
Key Laboratory for Green Chemical Process of Ministry of Education,Wuhan 430074,China
关键词:
维生素C泡腾片主组分吸湿性临界相对湿度
Keywords:
Vitamin Ceffervescence tabletmajor ingredientmoisture absorptioncritical relative humidity
分类号:
R944.4
DOI:
-
文献标志码:
A
摘要:
考察了维生素C泡腾片主组分的吸湿变化情况,为其生产制备环境提供理论支持.采用25 ℃、相对湿度为75%条件下测定各组分的吸湿速率和吸湿质量分数,确定吸湿平衡时间,在33%、43%、75%以及92.7%的湿度下测定平衡后的吸湿质量分数,对吸湿曲线分段拟合研究其吸湿动力学行为,并根据25℃不同湿度条件下的吸湿平衡曲线测定其临界相对湿度.将不同粒径的酒石酸进行吸湿对比实验.结果表明,维生素C、柠檬酸、蔗糖、酒石酸和碳酸氢钠的临界相对湿度分别为96%、74%、85%、83%、90%.根据吸湿平衡经验公式计算得到运用于生产车间的相对湿度53%(含柠檬酸)和61%(含酒石酸).各组分中吸湿快慢依次为柠檬酸、蔗糖、酒石酸、维生素C和碳酸氢钠.不同粒度的酒石酸,颗粒越小吸湿性越强.作为泡腾片原料,酒石酸稳定性要强于柠檬酸.
Abstract:
To review the change circumstance of moisture absorption of each content in Vitamin C effervescence tablet and to provide theoretic for its production environment. Measured the moisture absorption rate and moisture absorption percent of each ingredient at 25 ℃,75%relative humidity conditions,established the moisture absorption equilibrium time,and measured the moisture absorption percent at 33%,43%,75% and 92.7% humidity after equilibrium、studied the moisture absorption kinetics action by its subsection and fitting,and measured their critical relative humidity according to the moisture absorption equilibrium curve at 25 ℃,different humidity. The rsults show the critical relative humidity of Vitamin C,citric acid,sucrose,tartaric acid and sodium bicarbonate are 96%,74%,85%,83%,90%. The relative humidity used for production calculated according to the moisture absorption equilibrium experience formula are 53% (for citric acid) and 61% (for tartaric acid) respectively. For different granularity substance,the smaller the granule is, the stronger the moisture absorption is; the moisture absorption rate from fastest to slowest are citric acid,sucrose,tartaric acid,Vitamin C and sodium bicarbonate in turn. The stability of effervescence tablet used tartaric acid as raw material is stronger than using citric acid.

参考文献/References:

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[8]邹莹,刘永琼,祝宏,等. 替硝唑在水溶液中溶解度的实验测定及关联[J]. 武汉工程大学学报,2008,1(1): 7-9.

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备注/Memo

备注/Memo:
收稿日期:20080916
作者简介:李萤(1983),女,湖北荆州人,硕士研究生.研究方向:药物分析.
指导老师:刘永琼,教授,硕士生导师.研究方向:药物合成,药物新剂型新制剂和天然药物研究.*通信联系人
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