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[1]伍甜甜,赵　睿,陈宇欣,等.海藻酸钠海绵的制备及其药物控释性能[J].武汉工程大学学报,2018,40(05):534-537.[doi:10. 3969/j. issn. 1674-2869. 2018. 05. 011]
　WU Tiantian,ZHAO Rui,CHEN Yuxin,et al.Preparation and Controlled Release Performance of Sodium Alginate Sponges as Drug Carrier[J].Journal of Wuhan Institute of Technology,2018,40(05):534-537.[doi:10. 3969/j. issn. 1674-2869. 2018. 05. 011]
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海藻酸钠海绵的制备及其药物控释性能(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
40
期数:
2018年05期
页码:
534-537
栏目:
材料科学与工程
出版日期:
2018-12-27

文章信息/Info

Title:
Preparation and Controlled Release Performance of Sodium Alginate Sponges as Drug Carrier
文章编号:
20180511
作者:
伍甜甜; 赵　睿; 陈宇欣; 蔡　卓; 喻湘华; 李　亮*
武汉工程大学材料科学与工程学院，湖北 武汉 430205
Author(s):
WU Tiantian;  ZHAO Rui;  CHEN Yuxin;  CAI Zhuo;  YU Xianghua;  LI Liang*
School of Materials Science and Engineering，Wuhan Institute of Technology，Wuhan 430205，China
关键词:
海藻酸钠; 载药海绵; 环丙沙星; 药物释放
Keywords:
sodium alginate; drug-loaded sponge; ciprofloxacin; drug controlled release
分类号:
O633
DOI:
10. 3969/j. issn. 1674-2869. 2018. 05. 011
文献标志码:
A
摘要:
通过对海藻酸钠溶液进行冷冻干燥，以氯化钙为交联剂，制备出海藻酸钠海绵，再以此海绵为载体，负载环丙沙星，制得载药海藻酸钠海绵。研究了海藻酸钠溶液质量分数对海绵力学性能与吸水性能的影响，探究其对载药海绵的药物释放的影响。并进一步探索了载药海绵在不同外加电压下的药物释放行为。结果表明，随着海藻酸钠溶液质量分数的提高，所制得的海藻酸钠海绵的吸水率和吸水速度呈现先增加后减小的趋势，当海藻酸钠溶液质量分数为2.5%时，所得的海藻酸钠海绵的吸水率和吸水速度达到最大，药物释放率最高。海绵的药物释放速度和药物释放量随着电压的增大而加快，表明外加电压可以改变载药海绵的药物释放速率和释放量，从而为载药海藻酸钠海绵提供新的药物控释方法。
Abstract:
Sodium alginate sponges were prepared by freeze-drying sodium alginate and subsequent crosslinking with calcium chloride. The as-prepared sodium alginate sponges were used to load ciprofloxacin. The effects of the mass fraction of sodium alginate on the mechanical properties and water absorption capacities of sponges as well as the controlled release performance of ciprofloxacin-loaded sponges were investigated. The results indicated that the amount and rate of water absorption firstly increased and then decreased with the increase of the mass fraction of sodium alginate，being highest when the mass fraction of sodium alginate was 2.5%. The amount of drug-release was also highest at 2.5% of sodium alginate. Additionally，the controlled release performance of the drug-loaded sponges was also explored with the additional different voltages. The rate and amount of drug-release also increased with the increase of voltage，indicating the promotional role of the external voltage. It provides a new drug controlled release method for ciprofloxacin-loaded sodium alginate sponge.

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相似文献/References:

[1]张桥,鄢国平,程巳雪.点击化学反应原位制备海藻酸钠水凝胶[J].武汉工程大学学报,2011,(07):14.
　ZHANG Qiao,YAN Guoping,CHENG Sixue.Preparation of alginate hydrogels via “click” chemistry[J].Journal of Wuhan Institute of Technology,2011,(05):14.
[2]李　亮,喻航达,邱唯楚,等.海藻酸钠/氧化石墨烯复合水凝胶的制备与性能[J].武汉工程大学学报,2018,40(06):641.[doi:10. 3969/j. issn. 1674?2869. 2018. 06. 011]
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备注/Memo

备注/Memo:
收稿日期：2018-06-04基金项目：国家自然科学基金（51403167）；武汉工程大学第九届研究生教育创新基金（CX2017018）作者简介：伍甜甜，硕士研究生。E-mail：352859509@qq.com*通讯作者：李　亮，博士，教授。E-mail： msell08@163.com引文格式：伍甜甜，赵睿，陈宇欣，等. 海藻酸钠海绵的制备及其药物控释性能［J］. 武汉工程大学学报，2018，40（5）：534-537.
更新日期/Last Update: 2018-10-23