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[1]李阳,黄翔,陈达,等.5-芳基-3-羟基异噁唑的合成[J].武汉工程大学学报,2011,(05):18-21.[doi:10.3969/j.issn.16742869.2011.05.006]
　LI Yang,HUANG Xiang,CHEN Da,et al.Synthesis of 5arylsubstituted3hydroxyisoxazoles [J].Journal of Wuhan Institute of Technology,2011,(05):18-21.[doi:10.3969/j.issn.16742869.2011.05.006]
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年05期
页码:
18-21
栏目:
化学与化学工程
出版日期:
2011-05-31

文章信息/Info

Title:
Synthesis of 5arylsubstituted3hydroxyisoxazoles
文章编号:
16742869(2011)05001804
作者:
李阳; 黄翔; 陈达; 龚占强; 巨修练
武汉工程大学化工与制药学院，绿色化工过程省部共建教育部重点实验室，湖北 武汉 430074
Author(s):
LI Yang; HUANG Xiang; CHEN Da; GONG Zhanqiang; JU Xiulian
Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering and Pharmacy,
Wuhan Institute of Technology ,Wuhan 430074,China
关键词:
异噁唑; 合成; 杂环化合物
Keywords:
isoxazole;  synthesis;  heterocyclic compounds
分类号:
O626.13
DOI:
10.3969/j.issn.16742869.2011.05.006
文献标志码:
A
摘要:
以不同取代的苯甲醛为起始原料，经wittig反应,溴加成,关环得到5芳基3异噁唑醇.报道了对5个5-芳基-3-羟基噁唑化合物的新合成路线，这些目标化合物结构均经1H NMR和MS表征.并对化合物的wittig反应机理和关环反应机理进行了讨论.
Abstract:
Five 5–arylsubstituted3hydroxyisoxazoles were synthesized from aromatic aldehydes by means of wittig reaction, bromide reaction,and cyclization. All of the target compounds have been confirmed by 1H NMR, MS spectrums and elementary analysis. In addition, the possible mechanism of wittig reaction and the cyclization route was discussed.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：20110327作者简介：李阳（1985），女，江西鹰潭人，硕士研究生.研究方向：杂环化合物合成.指导老师：巨修炼，教授，博士，博士研究生导师.研究方向：计算机药物辅助设计、新农药研发、生物活性测试.*
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