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[1]陈达,李阳,余勇,等.苯基吡唑类衍生物的合成[J].武汉工程大学学报,2010,(05):31-34.[doi:10.3969/j.issn.16742869.2010.05.009]
　CHEN Da,LI Yang,YU Yong,et al.Synthesis of phenylpyrazole derivatives[J].Journal of Wuhan Institute of Technology,2010,(05):31-34.[doi:10.3969/j.issn.16742869.2010.05.009]
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2010年05期
页码:
31-34
栏目:
化学与化学工程
出版日期:
2010-05-31

文章信息/Info

Title:
Synthesis of phenylpyrazole derivatives
文章编号:
16742869(2010)05003103
作者:
陈达; 李阳; 余勇; 巨修练*
武汉工程大学化工与制药学院，湖北省新型反应器与绿色化学工艺重点实验室， 湖北 武汉 430074
Author(s):
CHEN Da;  LI Yang; YU Yong;  JU Xiulian
Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology,
School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan 430074，China
关键词:
苯基吡唑类衍生物; 烷基化; 酰胺化; 路易斯酸
Keywords:
phenylpyrazole derivatives;  alkylation;  amidation;  lewis acid
分类号:
O625.6
DOI:
10.3969/j.issn.16742869.2010.05.009
文献标志码:
A
摘要:
以2，6二氯4三氟甲基苯胺为原料，与2，3二氰基丙酸乙酯关环生成1(2，6二氯4三氟甲基)苯基3氰基5氨基吡唑，再在吡唑环4位氨基分别引入酰基或者烷基，合成了共9个苯基吡唑类衍生物，其中7个未见文献报道.所有目标化合物均通过熔点确认、1H NMR和MS表征.
Abstract:
9 Phenylpyrazole derivatives(7 new compounds) were synthesized by Scheme 1, starting with 2,6dichloro4trifluoromethyl aniline as material, via cyclization, synthesis of the intermediate 1(2,6dichloro4trifluoromethylphenyl)3Cyano5aminopyrazole, then introducing alkyl or acyl to 4NH2 of pyrazole ring. And all the target compounds were confirmed by melting point, 1H NMR and MS.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：20100314作者简介：陈达(1983)，男，浙江海宁人，硕士研究生.研究方向：药物合成、多肽合成.指导老师：巨修练，教授，博士，博士研究生导师.研究方向：药物合成.
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