|本期目录/Table of Contents|

[1]姚　思,李延东,胡琦薇,等.健那绿B的合成及其中放流程的设计[J].武汉工程大学学报,2016,38(3):240-243.[doi:10. 3969/j. issn. 1674?2869. 2016. 03. 001]
　YAO Si,LI Yandong,HU Qiwei,et al.Synthesis of Janus Green B and Pilot Scale Process Design[J].Journal of Wuhan Institute of Technology,2016,38(3):240-243.[doi:10. 3969/j. issn. 1674?2869. 2016. 03. 001]
点击复制

健那绿B的合成及其中放流程的设计(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
38
期数:
2016年3期
页码:
240-243
栏目:
化学与化学工程
出版日期:
2016-06-22

文章信息/Info

Title:
Synthesis of Janus Green B and Pilot Scale Process Design
作者:
姚　思; 李延东; 胡琦薇; 赵光然; 万春杰*; 吴风收; 汪宇航
武汉工程大学化工与制药学院，湖北 武汉 430074
Author(s):
YAO Si;  LI Yandong;  HU Qiwei;  ZHAO Guangran;  WAN Chunjie*;  WU Fengshou;  WANG Yuhang
School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430074, China
关键词:
健那绿B; 合成; 亚甲基紫3RAX; 中放流程
Keywords:
Janus Green B;  synthesis;  3RAX;  pilot technological procedure
分类号:
TQ620.6
DOI:
10. 3969/j. issn. 1674?2869. 2016. 03. 001
文献标志码:
A
摘要:
为了实现健那绿B的大规模生产，填补国内该领域的产业缺口，借助于模拟类推法，设计了健那绿B的两条合成路线. 以4-氨基-N， N-二乙基苯胺或对苯二胺（含N， N-二乙基苯胺）为起始原料，在重铬酸钾的存在下，与苯胺环合，得到亚甲基紫3RAX，再经过重氮化、偶合反应制备了健那绿B，总收率分别为29.5%和24.9%. 同时，对健那绿B的工艺过程进行了中放流程设计，编制了工艺流程框图以及带控制点的工艺流程图，并提出了生产过程中含铬废水的初步处理方法，为工业化实施奠定了工艺基础.
Abstract:
To achieve mass production of Janus Green B and fill the domestic gap in the field of industry production, we designed two synthetic routes for Janus Green B through analogy. N, N-diethyl-1, 4-phenylenediamine, or p-phenylenediamine （containing N, N-diethylaniline） was subjected to cyclization reaction with aniline to obtain 3RAX in the presence of potassium dichromate, then Janus Green B was prepared after diazotization and coupling reaction. The total yields of Janus Green B obtained are 29.5% and 24.9%, respectively. At the same time, the pilot technological procedure of Janus Green B was designed, and the technological process and process diagram with control points were drawn up. Meanwhile a preliminary approach was proposed for treating process wastewater containing chromium, which lays the foundation for the implementation of the industrialization process. Keywords： Ja

参考文献/References:

［1］　?ZDEMIR N， ?ZDEMIR S， BI?ER E. Interaction between janus green b and bovine serum albumin： electrochemistry and spectroscopy studies［J］. Chinese chemical letters， 2011， 22（6）： 717-720. ［2］　WEI Y J， TONG S Y， LI K A. Study on the interaction of bioactive substances with spectroscopic probes-interaction of serum albumin with chromazurol S in acidic solution［J］. Acta Chemia Sinica， 1995， 53： 83-89. ［3］　TUITE E， KELLY J M. The interaction of methylene blue， azure B， and thionine with DNA： formation of complexes with polynucleotides and mononucleotides as model systems［J］. Biopolymers，1995，35（5）：419- 433. ［4］　GAO H W， XU W Q. Langmuir aggregation of Evans blue on cetyltrimethylammonium bromide and on proteins and its application［J］. Analytica chimica acta， 2002， 458（2）： 417-424. ［5］　SUN W， JIAO K， HAN J， et al. A linear sweep voltammetric determination of proteins with thorin［J］. Acta chimica slovenica， 2006， 53（3）： 367. ［6］　SAITO T， TSUJIMOTO Y. Electrochemical study of multi-component additive behavior during copper electrodeposition with a microfluidic device and an electrochemical quartz crystal microbalance［J］. Japanese journal of applied physics， 2015，54：1-5. ［7］　茅晓晖， 史鸿鑫， 武宏科， 等. 吩嗪的合成及其应用［J］. 化工生产与技术， 2009， 16（3）： 42-47. MAO X H，SHI H X， WU H K， et al. Synthesis and application of phenazine［J］. Chemical production and technology， 2009，16（3）：42-47. ［8］　李陶琦， 解秋莲， 刘建利， 等. 3， 7-二氨基-2， 8-二甲基-5-苯基吩嗪盐酸盐合成研究［J］. 应用化工， 2011， 40（1）： 124-127. LI T Q，XIE Q L，LIU J L， et al. Study on synthesis of 3，7-diamino-2，8-dimethyl-5-5phenylphenium chloride［J］. Applied chemical industry，2011，40 （1）：124- 127. ［9］　王谦， 李延，孙平，等. 含铬废水处理技术及研究进展［J］. 环境科学与技术， 2013， 36（12）： 150-156. WANG Q，LI Y，SUN P，et al. The treatment technology and research progress of hexavalent chromium-containing wastewater ［J］. Environmental science & technology，2013，36（12）：150-156. ［10］ KANMANI P， ARAVIND J， PRESTON D. Remediation of chromium contaminants using bacteria［J］. International journal of environmental science and technology， 2012， 9（1）： 183-193. ［11］ BARAKAT M A. New trends in removing heavy metals from industrial wastewater［J］. Arabian journal of chemistry， 2011， 4（4）： 361-377.本文编辑：张 瑞

相似文献/References:

[1]张立娟,张珩*,杨艺虹,等.瑞巴匹特羧乙酯的合成[J].武汉工程大学学报,2009,(03):23.
　ZHANG Li juan,ZHANG Heng,YANG Yi hong,et al.Synthesis of diethyl ribamipide carboxylate[J].Journal of Wuhan Institute of Technology,2009,(3):23.
[2]王凯,邓艳丽,葛燕丽,等.2-氨基-4-甲氧基嘧啶的合成改进[J].武汉工程大学学报,2009,(07):16.
　WANG Kai,DENG Yan li,GE Yan li,et al.Synthetic innovation of 2amino4methoxypyrimidine[J].Journal of Wuhan Institute of Technology,2009,(3):16.
[3]章颖,肖欣,邓鹏星,等.1萘酚的β取代金属卟啉的合成及其抗菌活性[J].武汉工程大学学报,2008,(04):8.
　ZHANG Ying,XIAO Xin,DENG Peng xing,et al.Synthesis and antibacterial activity of βsubstituted metalporphyrins of 1naphthol[J].Journal of Wuhan Institute of Technology,2008,(3):8.
[4]林润锋,张珩*,杨艺虹,等.4氯2(N甲基N苯基胺磺酰基)苯甲酸甲酯的合成[J].武汉工程大学学报,2009,(12):5.
　LIN Run feng,ZHANG Heng,YANG Yi hong,et al.Synthesis of Methyl 4Chloro2(NmethylNphenylsulphonamide)benzoate[J].Journal of Wuhan Institute of Technology,2009,(3):5.
[5]周贤,王华,彭光菊,等.MES的合成及其磷矿浮选性能评价[J].武汉工程大学学报,2009,(12):48.
　ZHOU Xian,WANG Huan,PENG Guang ju,et al.Synthesis of MES and evaluation of its flotation properties to phosphate ores[J].Journal of Wuhan Institute of Technology,2009,(3):48.
[6]刘安昌,李高峰,夏强,等.4，4’二巯基二苯硫醚的合成[J].武汉工程大学学报,2010,(03):25.
　LIU An chang,LI Gao fen,XIA Qiang,et al.Study on the synthesis of 4,4′ thiobis(Benzenethio1)[J].Journal of Wuhan Institute of Technology,2010,(3):25.
[7]王勇,冯菊红,巨修练*.新型咪唑啉酮衍生物的合成研究[J].武汉工程大学学报,2010,(03):37.
　WANG Yong,FENG Ju hong,JU Xiu lian.Synthesis of novel 2arylheterocyclicamino3aryl5arylidene4Himidazolin4one Derivatives[J].Journal of Wuhan Institute of Technology,2010,(3):37.
[8]申永存,徐维赟.1S二苯基膦2R二(3，5二甲基苯基)膦二茂铁的合成[J].武汉工程大学学报,2010,(05):22.[doi:10.3969/j.issn.16742869.2010.05.006]
　SHEN Yong cun,XU Wei yun.Synthesis of (R)1［(S)2（Diphenylphosphino）ferrocenyl］ethyldi3,5xylylphosphine[J].Journal of Wuhan Institute of Technology,2010,(3):22.[doi:10.3969/j.issn.16742869.2010.05.006]
[9]段蓉,刘洋,黄齐茂,等.碘比醇的合成与表征[J].武汉工程大学学报,2010,(05):25.[doi:10.3969/j.issn.16742869.2010.05.007]
　DUAN Rong,LIU Yang,HUANG Qi mao,et al.Synthesis and characterization of iobitridol[J].Journal of Wuhan Institute of Technology,2010,(3):25.[doi:10.3969/j.issn.16742869.2010.05.007]
[10]周巍,黄翔,巨修练*.3，5二甲基4叔丁基2，6，7双环硫化磷酸酯的合成[J].武汉工程大学学报,2010,(05):28.[doi:10.3969/j.issn.16742869.2010.05.008]
　Zhou Wei,Huang Xiang,Ju Xiu Lian*.Synthesis of 3，5dimethyl4tbutylbicyclophosphorothionate[J].Journal of Wuhan Institute of Technology,2010,(3):28.[doi:10.3969/j.issn.16742869.2010.05.008]

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2016-06-23