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[1]吴江渝,黄维哲,周婷,等.三（2氨基乙基）胺核聚酰胺胺树形分子的合成[J].武汉工程大学学报,2014,(04):45-49.[doi:103969/jissn16742869201404010]
　WU Jiang yu,HUANG Wei zhe,ZHOU Ting,et al.Synthesis and characterization of polyamidoamine dendrimer using tris(2aminoethyl)amine as core[J].Journal of Wuhan Institute of Technology,2014,(04):45-49.[doi:103969/jissn16742869201404010]
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三（2氨基乙基）胺核聚酰胺胺树形分子的合成(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2014年04期
页码:
45-49
栏目:
材料科学与工程
出版日期:
2014-04-30

文章信息/Info

Title:
Synthesis and characterization of polyamidoamine dendrimer using tris(2aminoethyl)amine as core
文章编号:
16742869(2014)04004505
作者:
吴江渝; 黄维哲; 周婷; 何紫莹
武汉工程大学材料科学与工程学院，湖北 武汉 430074
Author(s):
WU Jiangyu; HUANG Weizhe; ZHOU Ting; HE Ziying
School of Materials Science and Engineering,Wuhan Institute of Technology,Wuhan 430074，China
关键词:
聚酰胺胺; 树形分子; 三（2氨基乙基）胺; 结构表征
Keywords:
polyamidoamine; dendrimer; tris(2aminoethyl)amine;  structural characterization
分类号:
O633.4
DOI:
103969/jissn16742869201404010
文献标志码:
A
摘要:
为了增大树形分子的表面官能团密度，降低其结构柔顺性，以三（2氨基乙基）胺为原料合成了一种新核树形分子.通过与丙烯酸甲酯在避光条件下的迈克尔加成反应得到末端为酯基的0.5代树形分子，将得到的产物与乙二胺进行酰胺化反应制得末端为氨基的1.0代树形分子.重复以上两个反应，合成得到1.0代到4.0代以三（2氨基乙基）胺为核的聚酰胺胺树形分子.反应过程中，运用薄层层析色谱检验以及观察红外光谱中酯基峰的消失与出现判断反应程度.每一步得到的粗产品采用柱层析分离的方法和乙醚沉降法进行分离提纯，并通过红外光谱和核磁共振氢谱对所得化合物的分子结构进行表征，证明了所得化合物即为目标化合物.三（2氨基乙基）胺的引入使得所合成的树形分子具有较小的核单元.
Abstract:
To enlarge endgroup density and decrease molecular flexibility,tris(2aminoethyl)amine was used for the synthesis of new core dendrimers.Esterterminating 0.5 generation polyamidoamine dendrimers with a tris(2aminoethyl)amine core were synthesized through Michael addition using methyl acrylate as reactant in the dark，then they were used as reactant to synthesize aminoterminating 1.0 generation polyamidoamine dendrimers by amidation reaction; finally,generation 1.0 to generation 4.0 polyamidoamine dendrimers with a tris(2aminoethyl)amine core were synthesized through iterative reactions.The extent of reactions was estimated through layer chromatograph and the ester peak was observed in fourier transform infrared spectra.The raw products were purified using column chromatography and sedimentation process.Fourier transform infrared and 1H nuclear magnitic resonance spectra were used for characterization.The core units of dendrimers decrease by introducing tris(2aminoethyl)amine.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：20131218基金项目：国家自然科学基金（51003081）作者简介：吴江渝(1977)，男，广东电白人，教授，博士.研究方向：树形分子合成及应用、丙烯酸系聚合物合成及应用、纳米二氧化硅材料的生物修饰.
更新日期/Last Update: 2014-05-15