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[1]胡学雷 孟美娜 姜治平 张道霞 甘东东 曾令康 葛燕丽.新型双臂大环稀土配合物的合成、表征与生物活性研究[J].武汉工程大学学报,2014,(03):1.
　HU Xue-lei,MENG Mei-na,JIANG Zhi-pingZHANG Dao-xia,et al.Synthesis, characterization and biological activities of Lanthanide Complex with Suspended-armed Macrocyclic Ligand[J].Journal of Wuhan Institute of Technology,2014,(03):1.
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新型双臂大环稀土配合物的合成、表征与生物活性研究()
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2014年03期
页码:
1
栏目:
出版日期:
2014-03-31

文章信息/Info

Title:
Synthesis, characterization and biological activities of Lanthanide Complex with Suspended-armed Macrocyclic Ligand
作者:
胡学雷 孟美娜 姜治平 张道霞 甘东东 曾令康 葛燕丽
(武汉工程大学化工与制药学院绿色化工过程教育部重点实验室,湖北 武汉430074)
Author(s):
HU Xue-lei ;  MENG Mei-na;  JIANG Zhi-pingZHANG Dao-xia;  GAN Dong-dong;  ZENG Ling-kang;  YANG JunGE Yan-li
(Key Laboratory for Green Chemical Process of Ministry of EducationSchool of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Hubei Wuhan 430074)
关键词:
稀土; 大环配体; 切割DNA; 抑菌
Keywords:
Rare earth; Macrocyclic complex; DNA cleavage; Inhibition of Escherichia coli
分类号:
-
DOI:
-
文献标志码:
-
摘要:
本工作用2，6-二甲酰基-4-甲基苯酚和三（3-氨基丙基）胺(trpn)稀土离子存在下通过[2+2]模板缩合反应直接合成了一个新型的双臂大环稀土铒配合物[ErL]ClO4·2H2O。通过元素分析、红外光谱、紫外光谱和电喷雾质谱对其进行表征。通过紫外光谱法、荧光光谱法和凝胶电泳实验考察了配合物与DNA的相互作用。研究结果表明：标题配合物对DNA具有一定的切割活性，且是以插入方式与小牛胸腺DNA结合。同时抑菌毒性实验证实了配合物对大肠杆菌也有一定的抑制作用。
Abstract:
a new suspended-armed macrocyclic lanthanide complex [ErL]ClO4?H2O was synthesized by [2+2] condensation of 2, 6- diformyl -4- methyl phenol and three (3- aminopropyl) amine (trpn) in the presence of Er3+ ion, and characterized by elemental analysis , infrared spectra , UV-Vis spectra and electrospray mass spectra. The interaction of the title complex with DNA was studied by UV-Vis spectra, fluorescence spectra and agarose gel electrophoresis. The results of UV-absorption and fluorescence characterization on the interaction of the title complex with Calf thymus DNA show that the title complex bind to DNA mainly in an intercalating mode. The results of a bio indicator bacteria of experiment about antibacterial toxicity show that the title complexes have inhibiting effect on Escherichia coli

参考文献/References:

[1] Alexander V. Design and synthesis of macrocyclic and their complexes of lanthanides and actinides[J]. Chem.Rev.1995(2): 95:273-342.
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HU Xei-lei，QIU Li, CHEN Zhong, et al. Synthesis, Crystal Structure and DNA Cleavage of a New Holmium(III) Nitrate with a Schiff-based Macrocyclic Ligand[J]. 2008，Acta Chimica Sinica, 66(12):1446-1450.(in chinese)
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ZHANG Yang-Ling, QIU Li, ZENG, Hui-Ling, et al. The Synthesis and characterization of a new asymmetric gadolinium (III) nitrate with a macrocyclic ligand. J ournal of Wuhan Institute of Technology, 2008, 30(4): 39-41. (in chinese)
[7] 胡学雷，邱立，高锋，等. 异双核Ag(I)Cu(I)穴合物的合成, 武汉工程大学学报，2007，29(2)：8-10.
HU Xei-lei，QIU Li, GAO Feng, et al. J ournal of Wuhan Institute of Technology, The Synthesis of a heterodinuclear (Cu(I),Ag(I)) cryptate, 2007，29(2)：8-10. (in chinese)
[8] 王银平，吴起峰，夏雨佳，等．Ho(III)希夫碱大环配合物的合成、晶体结构及其对ＤＮＡ的切割活性研究[J]．高等学校化学学报，2010,31(12): 2344-2348.
WANG Yin-Ping, WU Qi-Feng, XIA Yu-Jia, et al. Chemical journal of chinese universities, 2010,31(12): 2344-2348. (in chinese)
[9] ，，，.含吡啶基的多氮亚胺穴醚稀土配合物的合成与表征[J]. 稀土.2006，27(1)：90-92.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-03-04