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[1]冯菊红,龚昕,荣霞,等.新型N-苯甲酰基硝基胍类化合物的合成及其杀菌活性[J].武汉工程大学学报,2013,(12):44-47.[doi:103969/jissn16742869201312009]
　FENG Ju\|hong,GONG Xin,RONG Xia,et al.Synthesis and fungicidal activity of novel N\|benzoyl nitroguanidine derivatives[J].Journal of Wuhan Institute of Technology,2013,(12):44-47.[doi:103969/jissn16742869201312009]
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新型N-苯甲酰基硝基胍类化合物的合成及其杀菌活性(/HTML)

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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:: 2013年12期

页码:: 44-47

栏目:: 化学与化学工程

出版日期:: 2013-12-31

文章信息/Info

Title:: Synthesis and fungicidal activity of novel N\|benzoyl nitroguanidine derivatives

文章编号:: 16742869(2013)12004404

作者:: 冯菊红; 龚昕; 荣霞; 巨修练*; 武汉工程大学化工与制药学院,绿色化工过程教育部重点实验室，湖北武汉 430074

Author(s):: FENG Ju\|hong; GONG Xin; RONG Xia; JU Xiu\|lian; Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology,Wuhan 430074,China

关键词:: 苯甲酰基; 硝基胍衍生物; 杀菌活性

Keywords:: benzoyl; nitroguanidine derivatives; fungicidal activity

分类号:: TQ031.2

DOI:: 103969/jissn16742869201312009

文献标志码:: A

摘要:: 为了得到具有较强杀菌活性的新型硝基胍化合物，以硝酸胍为起始原料，通过硝基化反应和取代反应，得到具有不同取代基的硝基胍化合物，再通过酰化反应，将硝基胍化合物与苯甲酰氯反应，得到6个未见文献报道的N\|苯甲酰基硝基胍衍生物.目标化合物的结构通过核磁共振氢谱和质谱进行了表征，并采用平皿生长速率法对所合成的化合物进行了初步的杀菌活性测试，结果表明：在200 μg/mL质量浓度下，化合物2b和2c对草坪褐斑菌的抑制活性分别为90.7％和87％，高于阳性对照恶霉灵.

Abstract:: To obtain the novel nitroguanidine derivatives with potent fungicidal activities,guanidine nitrate was used as the starting material.The substituted nitroguanidine compounds were given by the nitration and alkylation reactions with the guanidine nitrate.Six novel benzoyl nitroguanidine derivatives were designed and synthesized by the acylation reactions of benzoyl chloride with the substituted nitroguanidine compounds.The structures of the target molecules were characterized by nuclear magnetic resonance spectrum and mass spectrum.The preliminary fungicidal activities tests of the synthesized compounds were measured using plate growth rate method. The results show that inhibition rate of 2b and 2c at 200 μg/mL against Rhizoctonia solani AG\|1\|IB is 90.7% and 87.0%,respectively;the activities of 2b and 2c are better than those of positive control hymexazol.

参考文献/References:

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备注/Memo

备注/Memo:: 收稿日期：20130918基金项目：湖北省教育厅科学技术研究计划优秀中青年人才项目（Q20091505）作者简介：冯菊红（1977\|），女，湖北襄阳人，讲师，博士.研究方向：药物化学.*通信联系人

更新日期/Last Update: 2014-01-07