|本期目录/Table of Contents|

[1]鄢国平*,邵春桃,韩林,等.聚碳酸酯纳米药物的制备与性能[J].武汉工程大学学报,2013,(07):43-48,53.[doi:103969/jissn16742869201307009]
　YAN Guo ping,SHAO Chun tao,HAN Lin,et al.Synthesis and properties of polycarbonate nanoparticles drugs[J].Journal of Wuhan Institute of Technology,2013,(07):43-48,53.[doi:103969/jissn16742869201307009]
点击复制

聚碳酸酯纳米药物的制备与性能(/HTML)
分享到：

《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2013年07期
页码:
43-48,53
栏目:
资源与土木工程
出版日期:
2013-07-31

文章信息/Info

Title:
Synthesis and properties of polycarbonate nanoparticles drugs
文章编号:
16742869(2013)07004306
作者:
鄢国平*; 邵春桃; 韩林; 邹头君; 刘凡; 龚晓芸; 常秀鹏
武汉工程大学材料科学与工程学院，湖北 武汉430074;武汉工程大学绿色化工过程教育部重点实验室，湖北 武汉 430074
Author(s):
YAN Guoping; SHAO Chuntao; HAN Lin; ZOU Toujun; LIU Fan; GONG Xiaoyun; CHANG Xiupeng
School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan 430074, China;Key Laboratoryfor Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430074, China
关键词:
生物材料; 纳米药物; 药物控制释放
Keywords:
biomaterials;  polymeric nanoparticles and microspheres;  drug controlled release
分类号:
TM 344.1
DOI:
103969/jissn16742869201307009
文献标志码:
A
摘要:
采用可生物降解高分子材料链接或包埋抗癌药物制备高分子纳米或微米药物,不仅可以提高药物的抗癌功效而且能减小药物对正常组织的毒副作用.以9苯基2,4,8,10四氧螺\[5,5\]十一烷3酮与2,2二甲基二亚甲基合成的羟基化的碳酸酯共聚物P(PTCcoDTC)为载体，将肿瘤靶向基团叶酸通过化学反应键连在聚碳酸酯的侧链,从而制备肿瘤靶向性高分子载体，并进行了傅立叶红外光谱、核磁共振氢谱、紫外可见光谱等结构表征.再将靶向高分子载体与5氟尿嘧啶复合，采用高压电场喷雾法与透析法分别制得两种肿瘤靶向聚碳酸酯纳米抗癌药物，并初步研究了纳米抗癌药物的体外药物控制释放性能.研究结果表明碳酸酯纳米药物具有较好的药物释放性能,且高压电场喷雾法制备的纳米药物比透析法制备的纳米药物释放药物速率快.
Abstract:
The polymer nanoparticles and microspheres are usually prepared by the entrapment and attachment of the anticancer drugs using biodegradable polymer materials as the carriers. These drug delivery systems can not only increase anticancer efficacy, but also reduce the toxicity of drugs to normal tissues. In this work, the tumertargeting polycarbonates were prepared by the incorporation of folic acid(FA) as a tumertargeting group into the partly deprodected polycarbonate P(DTCcoPTC) containing hydroxyl group. Sequently, the tumertargeting polycarbonate anticancer nanoparticles and microspheres were prepared by the highvoltage electrostatic fieldassisted atomization and dialysis methods using 5fluorouracil(5Fu) as an anticancer drug model and the tumertargeting polycarbonates containing FA groups as polymer carriers. These polycarbonates anticancer nanoparticles and microspheres were further characterized and their properties in vitro were also evaluated. The drug release tests indicate that these polycarbonates anticancer nanoparticles and microspheres retain the steady 5Fu release rates and have good controlled release properties. Moreover, polycarbonates nanoparticles prepared by highvoltage electrostatic fieldassisted atomization possess faster 5Fu release rates than that of polycarbonates anticancer microspheres prepared by dialysis method.

参考文献/References:

［1］刑宝玲, 张东生. 纳米医药技术在恶性肿瘤治疗中的应用\[J\]. 中国新药与临床杂志, 2004,23(5):303306.XING Baoling, ZHANG Dongsheng. Application of medical nanotechnology in treatment of malignant tumor\[J\]. Chinese Journal of New Drugs and Clinical Remedies,2004, 23(5): 303306.(in Chinese)［2］Chang C A. Magnetic resonance imaging contrast agents: design and physicochmical properties of gadodiamide\[J\]. Invest Radiol,1993,28(1):2227.［3］Ravi Kumar M N. Nano and microparticles as controlled drug delivery devices\[J\]. Pharm Sci,2000,3: 234258.［4］蔡波涛, 薛大权. 靶向长效纳米粒的研究现状及展望\[J\]. 数理医药学杂志,2009,22(1):8384.［5］李会东. 纳米技术在生物学与医学领域中的应用\[J\]. 湘潭师范学院学报:自然科学版, 2005,27(2):4951.［6］Agnihotri S A, Aminabhavi T M. Controlled release of clozapine through chitosan microparticles prepared by a novel method\[J\]. Journal of Controlled Release,2004,96(2):245259.［7］Lu H X, Li B, Kang Y, et al. Paclitaxel nanoparticle inhibits growth of Ovarian cancer xenografts and enhances lymphatic targeting\[J\]. Cancer Chemother Pharmac,2007,59:175181.［8］王婧,胡宏伟,刘根新,等. 纳米药物靶向作用的研究现状\[J\]. 安徽农业科学,2008,36(34):1501915021. WANG Jing，HU Hongwei,LIU Genxin, et al. Study Progress on Nanodrugs Targeted Effect\[J\]. Journal of Anhui Agricultural Sciences,2008,36(34):1501915021. (in Chinese)［9］王子妤,张东生. 纳米药物的研究进展\[J\]. 东南大学学报, 2004,23(2):131135. WANG Ziyu, ZHANG Dongsheng. The advance in research of nanomedicine\[J\]. Journal of Southeast University, 2004, 23(2): 131135. (in Chinese)［10］Ehtezazi T, Washingto C. Controlled release of macromolecules from PLA microspheres: using porous structure topology\[J\]. J Control Release,2000,142(68):361372.［11］Young S W, Wright M, Sessler J L, et al. Texaphyrinlipophilic molecular vesicle complexes, membrane incorporation of texaphyrins, and use in diagnosis and therapy\[P\]. PCT Int Appl WO,9746262,1997,1112.［12］Li Heping, Ruan Jianming,Ding Zhiwei. Progress on the Studies of Nanocontrolled Release Anticancer Drugs\[J\]. Shandong Journal of Biomedical Engineering. 2003(3):4851.［13］吴元魁，方挺松，陈大朝，等. GdDTPA和HASGdDTPA应用于MR淋巴造影的对比研究\[J\].南方医科大学学报,2007(10):194196.WU Yuankui，FANG Tingsong，Chen Dachao，etal. A comparative study of GdDTPA and HSAGdDTPA in magnetic resonance lymphography\[J\]. Journal of Southern MedicalUniversity,2007(10):194196. (in Chinese)［14］艾朝武. 脂肪族碳酸酯共聚物与电子顺磁共振成像诊断剂的合成与性能研究\[D\]. 武汉：武汉工程大学, 2010.AI Chaowu. Synthesis and Properties of Aliphatic Polycarbonate Copolymers and EPR Imaging Contrast Agents\[D\]. Wuhan: Wuhan Institute of Technology,2010. (in Chinese)［15］陈辉. 可生物降解碳酸酯共聚物与纳米抗癌药物的制备及性能研究\[D\]. 武汉：武汉工程大学, 2009.Chen Hui. Synthesis and Properties of Biodegradable Carbonates Copolymers and Anticancer Nanaparticles\[D\].Wuhan:Wuhan Institute of Technology,2009. (in Chinese)

相似文献/References:

[1]张桥,鄢国平,程巳雪.点击化学反应原位制备海藻酸钠水凝胶[J].武汉工程大学学报,2011,(07):14.
　ZHANG Qiao,YAN Guoping,CHENG Sixue.Preparation of alginate hydrogels via “click” chemistry[J].Journal of Wuhan Institute of Technology,2011,(07):14.

备注/Memo

备注/Memo:
收稿日期：20130418基金项目：国家自然科学基金面上项目(51173140)；武汉市科技攻关项目(2013010501010131);2012年地方高校第二批国家级大学生创新创业训练计划项目（1002120203）;武汉工程大学第三届研究生创新基金(CX201144)；武汉工程大学第四届研究生教育创新基金（CX201231）；武汉工程大学第八期大学生校长基金项目（2013049）作者简介：鄢国平(1970),男,湖北天门人，教授,博士研究生导师. 研究方向:功能高分子材料.*通信联系人
更新日期/Last Update: 2013-07-31