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[1]鄢国平,邹头君,邵春桃,等.含卟啉基团小分子钆配合物的合成与表征[J].武汉工程大学学报,2013,(02):1-5,10.[doi:103969/jissn16742869201302001]
　YAN Guo ping,ZOU Tou jun,SHAO Chun tao,et al.Synthesis and characterization of diethylene triamine triacetate acid?diactyl(5(4aminophenyl)10, 15, 20tripyridineporphyrin)?gadolinium complex （GdDTPA2APTMPyP）[J].Journal of Wuhan Institute of Technology,2013,(02):1-5,10.[doi:103969/jissn16742869201302001]
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含卟啉基团小分子钆配合物的合成与表征(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2013年02期
页码:
1-5,10
栏目:
资源与土木工程
出版日期:
2013-02-28

文章信息/Info

Title:
Synthesis and characterization of diethylene triamine triacetate acid?diactyl(5(4aminophenyl)10, 15, 20tripyridineporphyrin)?gadolinium complex （GdDTPA2APTMPyP）
文章编号:
16742869(2013)02000105
作者:
鄢国平; 邹头君; 邵春桃; 李贞; 常秀鹏
武汉工程大学材料科学与工程学院，湖北 武汉 430074；武汉工程大学绿色化工过程教育部重点实验室，湖北 武汉 430074
Author(s):
YAN Guoping; ZOU Toujun; SHAO Chuntao; LI Zhen; CHANG Xiupeng
School of Material Science and Engineering, Key Laboratory for Green Chemical?Process of Ministry Education, Wuhan Institute of Technology, Wuhan 430074, China
关键词:
磁共振成像; 造影剂; GdDTPA; 卟啉
Keywords:
magentic resonance imaging(MRI);  contrast agent;  relaxivity;  GdDTPA;  porphyrin
分类号:
TM 344.1
DOI:
103969/jissn16742869201302001
文献标志码:
A
摘要:
针对临床上广泛应用的磁共振成像造影剂二乙三胺五乙酸钆（GdDTPA）是一种离子型造影剂，由于其成像时间短、渗透压较高，没有组织或器官选择性(靶向性)，尤其对早期肿瘤的成像检测效果较差的问题，利用卟啉对肿瘤的特异亲和性，将5（4氨基苯基）10，15，20三吡啶基卟啉与二乙三胺五乙酸双酸酐（DTPAA）进行化学反应，合成了一种小分子配体（DTPA2APTMPyP），再与金属钆离子Gd（Ⅲ）配合，从而制备了小分子磁共振成像造影剂（GdDTPA2APTMPyP）.并对所合成的配体及其配合物进行了红外光谱、紫外光谱与核磁共振等结构表征，证明产品为目标产物.同时初步测定了配合物的体外弛豫率与细胞毒性.实验表明，与临床应用的小分子造影剂二乙三胺五乙酸钆（GdDTPA）相比，这种小分子造影剂具有较高的弛豫率与略高的体外细胞毒性.
Abstract:
GdDTPA was the contrast agent widely used in clinical MRI for contrast enhancement. However, the short imaging time and the nonspecific distribution in vivo limit its utility in focal lesion detection and diagnosis.5(4Aminophenyl)10, 15, 20tripyridineporphyrin (APTMPyP) was chosen as a tumortargeting group.A ligand containing porphyrin groups was then synthesized by the incorporation of APTMPyP into diethylenetriaminepentaacetic dianhydride (DTPAA).This ligand obtained was further reacted with gadolinium chloride to make corresponding tumortargeting gadolinium complex GdDTPA2APTMPyP. The ligand and gadolinium complex were characterized by infrared spectrum,Fourier Transform Infrared Spectrometer(FTIR), Ultraviolet spectrometry(UV), etc and their properties in vitro were also evaluated. GdDTPA2APTMPyP possesses obviously higher relaxation effectiveness and slightly higher cytotoxicity to Hela cells than those of GdDTPA. Therefore GdDTPA2APTMPyP can be used as a potential contrast agent in targeted MRI to tumors.

参考文献/References:

［1］陈小华, 潘庆春. PTDHBcAg融合蛋白经树突状细胞诱导特性CTL抑制HBV的体外研究\[J\].细胞与分子免疫学杂志,2009,25(4):289292.

［2］汤俊琦, 黄嘉敏. 纳米金在肿瘤诊断中的应用\[J\].材料导报,2012,26(9):5964.
［3］Fries P, Runge V M, Bqucker A, et al. Brain tumor enhancement in magnetic resonance imaging at 3 tesla: intraindividual comparison of two high relaxivity macromolecular contrast media with a standard extracellular Gdchelate in rat brain tumor modal\[J\]. Invest Radiol,2009,44(4):200206.
［4］黄素英, 张婷. 冠脉造影剂肾病水化干预护理探讨\[J\]. 护士进修杂志,2011,26(8):698700.
［5］王兆星. 造影剂肾病早期诊断的生物标志物\[J\]. 肾脏病与透析肾移植杂志,2011,20(3):275279.
［6］Yan G P, Zhuo R X. Livertargeting macromolecular MRI contrast agents\[J\]; Science in China：Series B,2001,44(4):344352.［7］Yan G P, Liu M L. Polyaspartamide Gadolinium Complexes Containing Sulfadiazine Groups as Potential Macromolecular MRI Contrast Agents\[J\]. Bioconjugate Chem,2005,16(4):967971.［8］Yan G P, Ai C W, Li L, et al. Dendrimers as Carriers for Contrast Agents in Magnetic Resonance Imaging\[J\]. Chinese Science Bulletin,2010,55( 27/28 ):32373243.［9］侯长军,郝燕,霍丹群.卟啉及其衍生物抗癌活性机理研究进展\[J\].生物医学工程研究,2007,26(1):97100.［10］ShahbaziGahrouei D, Williams M, Rizvi S, et al. In Vivo Studies of GdDTPAmonoclonal Antibody and Gdporphyrins: Potential Magnetic Resonance Imaging Contrast Agents for Melanoma\[J\]. J Magn Reson Imaging,2001,14:169174.［11］Young S W, Sidhu M K, Qing F. Preclinical Evaluation of Gadolinium (III) Texaphyrin Complex: a New Paramagnetic Contrast Agent for Magnetic Resonance Imaging\[J\]. Invest Radiol,1994,29:330338.12］Hofmann B, Bogdanov A, Marecos E, et al. Mechanism of Gadophrin2 Accumulation in Tumor Necrosis\[J\].J Magn Reson Imaging,1999,9:336341.
［13］石伟民 , 刘卫敏 , 陶京朝. 用于光动力治疗的四苯基卟啉衍生物研究进展\[J\].化学研究，2005,16（2）：101105.
［14］Yan G P, Li Z, Xu W, et al. Porphyrincontaining Polyaspartamide Gadolinium Complexes as Potential Magnetic Resonance Imaging Contrast Agents\[J\]. International Journal of Pharmaceutics,2011,407:119125.
［15］张丽民, 陈杞. 螯合剂DTPAA的合成及应用\[J\].化学世界,1992,33(2):7072.
［16］Hnatowich D J, Layne W W. The preparation and labeling of DTPAcoupled albumin\[J\]. Int J Appl Radiat Isot,1982,33(5):327332.
［17］DongFang S, Richard T W, Daekyu S, et al. Laurence H. Hurley. QuadruplexInteractive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and StructureActivity Relationship for the Inhibition of Telomerase\[J\]. J Med Chem, 2001,44(26):45094523.

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备注/Memo

备注/Memo:
收稿日期：20121102基金项目：国家自然科学基金面上项目（51173140）；武汉市科技攻关计划项目（2013年批文待发）；武汉工程大学第三届研究生创新基金（CX201139）作者简介：鄢国平（1970），男，湖北天门人，教授，博士.研究方向：生物医用材料.
更新日期/Last Update: 2013-04-16