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[1]刘安昌,丁莉莉,赵慧平,等.新型除草剂甲磺胺磺隆[J].武汉工程大学学报,2011,(10):1-3.
　LIU An chang,DING Li li,ZHAO Hui ping,et al.New herbicide mesosulfuronmethyl[J].Journal of Wuhan Institute of Technology,2011,(10):1-3.
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2011年10期
页码:
1-3
栏目:
化学与化学工程
出版日期:
2011-11-30

文章信息/Info

Title:
New herbicide mesosulfuronmethyl
文章编号:
16742869(2011)10000103
作者:
刘安昌; 丁莉莉; 赵慧平; 姚珊; 陈涣友
武汉工程大学绿色化工过程教育部重点实验室，湖北 武汉 430074
Author(s):
LIU Anchang; DING Lili; ZHAO Huiping; YAO Shan; CHEN Huanyou
Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan  Institute of  Technology,Wuhan 430074,China
关键词:
甲磺胺磺隆; 生物活性; 作用方式; 合成
Keywords:
 ; mesosulfuronmethy; bioactivity; action mechanism; synthesis
分类号:
TQ460.3
DOI:
-
文献标志码:
AAdoi:10.3969/j.issn.16742869.2011.10.001
摘要:
针对甲磺胺磺隆属磺酰脲类属于新型高效除草剂，通过抑制乙酰乳酸合成酶而起作用；介绍了以对甲苯腈为起始原料合成甲磺胺磺隆的合成方法：对甲苯腈为原料，经硝化、氧化和酯化得到了4氰基2硝基苯甲酸甲酯；然后加氢，磺酰化等得到2磺酰胺4甲磺酰胺基甲基苯甲酸甲酯，2磺酰胺4甲磺酰胺基甲基苯甲酸甲酯与N（4,6二甲氧基嘧啶2基）甲酸苯酯反应得到甲磺胺磺隆.
Abstract:
 Mesosulfuronmethyl was a member of the sulfonylurea group of herbicides．Its mode of action was to inhibit the biosynthesis of essential amino acids in susceptible plants，through inhibition of acetolactate synthase (ALS)． The synthesis of the herbicide has been introduced：4cyano2nitrobenzoic methyl ester was synthesized with 4tolunitrile by nitrification, oxidation and esterification；4cyano2nitrobenzoic methyl ester was hydrogenated and sulfonated to give Methyl 2sulfonyl4methanesulfonylaminomethyl benzoate,which was the key Intermediate of Mesosulfuronmethyl. Then the Intermediate reacted with N(4,6dimethoxyprimidin2yl) phenylcarbamate to give the Mesosulfuronmethyl.

参考文献/References:

［1］Vazan S,Oveisi M,Baziar S.Efficiency of mesosulfuronmethyl and clodinafoppropargyl dose for the control of Lolium perenne in wheat［J］.Crop Protection，2011，30(6):592597.
［2］Kortagere S,Krasowski M D,Reschly E J,et al.Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database［J］.Environmental Health Perspectives，2010,118(10):14121417.
［3］Lazartigues A,Wiest L,Baudot R,et al.Multiresidue method to quantify pesticides in fish muscle by QuEChERSbased extraction and LCMS/MS［J］.Analytical and Bioanalytical Chemistry,2011,400(7):21852193.
［4］Allison B D,Hack M D,Phuong V K,et al.Preparation of 5［［(2carbamoylphenyl)amino］sulfonyl］quinoxaline compounds as cholecystokinin 2 modulators:US,20050038032［P］.20050217.
［5］Lorenz K,Ressel H J,Willms L.Method for the preparation of sulfonylaminomethylbenzoates as intermediates for producing sulfonylurea herbicides:WO,2002008176［P］.20020131.

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