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[1]章社生,何康,范宁,等.蛋白质空间结构数字特性统计分析及应用[J].武汉工程大学学报,2010,(05):45-48.[doi:10.3969/j.issn.16742869.2010.05.013]
 ZHANG She sheng,HE Kang,FAN Ning,et al.Statistical analysis and application of the protein structure[J].Journal of Wuhan Institute of Technology,2010,(05):45-48.[doi:10.3969/j.issn.16742869.2010.05.013]
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蛋白质空间结构数字特性统计分析及应用(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2010年05期
页码:
45-48
栏目:
机电与信息工程
出版日期:
2010-05-31

文章信息/Info

Title:
Statistical analysis and application of the protein structure
文章编号:
16742869(2010)05004504
作者:
章社生何康范宁晏臻王星
武汉理工大学理学院统计学系, 湖北 武汉 430070
Author(s):
ZHANG SheshengHE KangFAN NingYAN ZhenWANG Xing
Department of Statistics, School of Science, Wuhan University of Technology,Wuhan 430070,China
关键词:
蛋白质氨基酸数字特征生物统计
Keywords:
proteinthe amino acidfeaturesbiostatistics
分类号:
O213
DOI:
10.3969/j.issn.16742869.2010.05.013
文献标志码:
A
摘要:
研究了蛋白质分子的结构,从RCSB公共数据库中收集蛋白质PDB数据文件,利用统计分析和数据挖掘知识,建立了以蛋白质形心为原点的蛋白质原子空间坐标系,从蛋白质的数字特征入手,讨论了五类蛋白质(肌蛋白、血蛋白、激素、抗体、生物膜)的结构特性及数字特征的分布,其中激素分子相对其他几类蛋白质较小,原子的分布也相对集中;并讨论了20种残基的结构特性,构造出蛋白质数字特征能量函数,其结论有助于蛋白质生物功能开发和蛋白质设计研究.
Abstract:
The article mainly deals with the structure of protein molecules. With the PDB files collected from the RCSB public database and the knowledge of statistical analysis and data mining. We build a spatial coordinate system with the geometrical center of a specific protein molecule being the origin. After discussing the features of five kinds of protein (muscle protein, blood protein, hormones, antibodies, biomembrane), we study the structural characteristics as well as the distribution of the features respectively. Consequently, in terms of our analytical system, hormone molecules are relatively smaller and the distributions of their atoms are more concentrated compared with others. Meanwhile, the detailed discussion on the structural characteristics of 20 kinds of the amino acid residues is conducted. Furthermore, we develop energy function based on the features of these residues, which will contribute to the development of protein biological function as well as the design research.

参考文献/References:

[1]江凡.蛋白质空间结构的实验技术和理论方法[J].物理,2007,36(4):272279.
[2]王昕,毛炳蔚,王福伟,等.蛋白质空间结构的统计分析[J].山西大同大学学报:自然科学版,2008,24(5):38.
[3]沈世镒,胡刚,张华.氨基酸在蛋白质空间结构中的深度倾向性因子[J].生物数学学报,2007(7):305310.
[4]沈世镒,胡刚,张华.蛋白质空间形态特征分析与计算方法[J].工程数学学报,2006,22(2):225234.
[5]胡敏,彭群生.一种基于空间密度特征的蛋白质结构相似性判定方法[J].工程图学学报,2005,26(1):9095.
[6]王仲君,王能超,毛黎明.基于自回避搜索遗传算法的蛋白质折叠研究[J].武汉理工大学学报,2005,27(8):9195.
[7]Faraggi E,Yang Y, Zhang S,et al. Predicting continuous local structure and the effect of its substitution for secondary structure in fragmentfree protein structure prediction[J].Structure,2009,17:15151527.
[8]Liang S, Wang G, Zhou Y. Refining nearnative proteinprotein docking decoys by local resampling and energy minimization[J]. Proteins,2009,76:309316.
[9]Xue B, Faraggi E, Zhou Y. Predicting residueresidue contact maps by a twolayer, integrated neuralnetwork method[J].Proteins,2009,76:176183.
[10]张佑红,陈龙,靖志强,等.不同周期Sf9细胞琥珀酸脱氢酶酶活的研究 [J].武汉工程大学学报,2009,30(5):46.
[11]奚强,李俊,林丫丫,等. L核糖的合成[J].武汉工程大学学报,2009,30(5):1820.

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备注/Memo

备注/Memo:
收稿日期:20100304基金项目:国家自然科学基金(69773023)资助项,武汉理工大学自主创新研究基金(批准号09140716101)资助项目作者简介:章社生(1955),男,湖北鄂州人,教授,博士.研究方向:生物数学.
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