|本期目录/Table of Contents|

[1]齐兵,冯磊,陈达,等.水杨酸衍生物的合成及生物活性测定[J].武汉工程大学学报,2010,(01):49-52.
　QI Bing,FENG Lei,CHEN Da,et al.Synthesis and biological activity of salicylic acid derivatives[J].Journal of Wuhan Institute of Technology,2010,(01):49-52.
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水杨酸衍生物的合成及生物活性测定(/HTML)
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《武汉工程大学学报》[ISSN:1674-2869/CN:42-1779/TQ]

卷:
期数:
2010年01期
页码:
49-52
栏目:
化学与化学工程
出版日期:
2010-01-31

文章信息/Info

Title:
Synthesis and biological activity of salicylic acid derivatives
文章编号:
16742869(2010)01004904
作者:
齐兵;  冯磊;  陈达;  吴引超;  巨修练*
湖北省新型反应器与绿色化学工艺重点实验室； 武汉工程大学化工与制药学院， 湖北 武汉 430074
Author(s):
QI Bing;   FENG Lei;   CHEN Da;   WU Yinchao;   JU Xiulian
Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology,
 School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430074, China
关键词:
水杨酸;  合成;  草坪褐斑病菌;  水稻纹枯病菌;  抑制活性
Keywords:
 ; salicylic acid;  synthesis;  rhizoctonia solani AG1IB fusion group;  rice sheath blight;  inhibitory activity
分类号:
O621.3; S435.111.2
DOI:
-
文献标志码:
A
摘要:
以水杨酸为起始原料，设计及合成了6个水杨酸衍生物，6个目标化合物结构由1H NMR、MS和熔点确证.采用平皿生长速率法测定6个化合物对草坪褐斑病菌和对水稻纹枯病菌的抑制效果，所有化合物均表现出一定的抑菌活性.
Abstract:
 Six Salicylic acid derivatives were designed and prepared using Salicylic acid as the starting material. All compounds were characterized by MS, 1H NMR and melting point. Their inhibiting activity against Rhizoctonia solani AG1IB fusion group and Rice sheath blight were investigated by method of colony diameter and the results show that all compounds display a content of inhibitory activity.

参考文献/References:

1］杨冰. 几种水杨酸衍生物的合成及应用［J］. 化工之友, 2007, 15: 4849.
［2］Lanas A, Bajador E, Serrano P, et al. Nitrovasodilators, low dose aspirin, other non steroidal antiinflammatory drugs，and the risk of upper gastrointestinal bleeding［J］. N Engl J Med, 2000, 343(12): 834839.
［3］孙易, 季晖, 张奕华, 等. 一氧化氮供体偶联的阿司匹林衍生物II6抗血栓作用及其机制研究［J］. 中国药理学通报, 2006, 22(7): 840844.
［4］牟筱铃, 张子学. 水杨酸浸种对棉花幼苗抗旱性的影响［J］. 种子, 2008, 27(11): 5056.
［5］盂繁浩, 王立升, 贾伟儒. 非甾体抗炎药二氟尼柳的合成［J］. 精细化工, 2002, 19(5): 252253.
［6］Shoeb H  A. Synthesis and molluscicidal activity of some anilides［J］. Egyptian Journal of Chemistry, 1979, 22(3): 24554.
［7］Waisser K, Hladuvkova J, Kunes J, et al. Synthesis and antimycobacterial activity of salicylanilides substituted in position 5［J］. Chemical Papers, 2001, 55(2): 121129.
［8］Waisser K, Drazkova K, Cizmarik J, et al. Antimycobacterial Activity of Basic Ethyl Esters of Alkoxy Substituted Phenylcarbamic Acids［J］. Falia Microbial, 2003, 48(1): 4550.
［9］Markus K, Dahlgren, Anna M, et al. Design, Synthesis and Multivariate Quantitative StructureActivity Relationship of Salicylanilidess Potent Inhibitors of Type III Secretion in Yersinia［J］. J Med Chem, 2007, 50: 61776188.
［10］Kang D H, Joo T Y, Lee E H, et al A mild and efficient reaction for conversion of carboxylic acids into acid bromides with ethyl tribromoacetate/triphenylphosphine under acidfree conditions［J］. Tetrahedron Letters, 2006, 47: 56935696.
［11］Luo Qun Li, Li Jing Ya, Liu Zhi Ying, et al. Inhibitors of type I MetAPs containing pyridine2carboxylicacid thiazol2ylamide. Part 1: SAR studies on the determination of the key scaffold［J］. Bioorganic & Medicinal Chemistry Letters, 2005, 15: 635638.
［12］晁龙军, 单学敏, 车少臣, 等. 草坪褐斑病病原菌鉴定、流行规律及其综合控制技术的研究［J］. 中国草地, 2000, 4: 4348.
［13］韩新才, 石章鹏, 陶维红，等. 氯胺磷对水稻纹枯病菌的室内生物活性测定结果［J］. 湖北植保, 2007 （4）: 3739.
［14］魏红, 关秋业. 化学实验［M］. 北京:人民卫生出版社, 2005:518520.

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备注/Memo

备注/Memo:
收稿日期：20090702作者简介：齐兵（1983），男，湖北襄樊人，硕士研究生.研究方向：药物合成.指导老师：巨修练，男，教授，博士.研究方向：计算机药物辅助设计、新农药研发、生物活性测试.*通讯联系人.
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